PhD Projects

We develop a method to fast sequence a single DNA molecule, which can be further used for virus detection.

We used a machanical model to quantify how protein affects DNA melting within replisome under tension.

Transitionally exposed ssDNA during replication are coated and stabilized by single-stranded DNA binding protein (SSB) within the replisome. How these SSB protein regulates and are displaced by DNA polymerase (DNAp) however are still poorly understood. Here T7 DNAp and T7 gp2.5 (SSB) are used as model proteins to investigate their interaction.